Background: Epidermodysplasia verruciformis is a rare genodermatosis characterized by a unique susceptibility to\ncutaneous human papillomaviruses infection. Most patients show autosomal recessive patterns of inheritance.\nCase presentation: We report a case of two sisters with clinically epidermodysplasia verruciformis specific lesions\non the face, neck, trunk, and extremities. PCR analysis indicated the presence of human papillomavirus type 5 in the\nlesions. Electron microscopic examination showed viral-like particles in keratinocyte nuclei and the stratum corneum of\nthe epidermodysplasia verruciformis lesions. In addition, we examined the EVER1 and EVER2 genes using eight different\nprimer pairs without finding any nonsense or frameshift mutations in the gDNA from lymphocytes of the elder sister.\nConclusions: In this report, the patient�s parents did not have epidermodysplasia verruciformis lesions or a\nconsanguineous marriage. EV did not develop in the elder sister until five years of age, so the parents did not perceive\nEV as an inherited disease. The probability that EV developed in both sisters was only 6.25%. Thus, it is rare for both\nsisters to develop epidermodysplasia verruciformis lesions considering that the parents were presumed to be carriers\nand the disease reveal an autosomal recessive pattern of inheritance.
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